The Randox Biochip
The Evidence Investigator™ utilizes a biochip as a reaction platform. The biochip is a 9mm2 solid substrate with multiple specific ligands (antibodies or antigens) attached at pre-defined sites on the surface. At present up to 100 tests can be pre-fabricated onto the biochip surface. In the future the capacity of tests per biochip can be increased dramatically.

Randox Methodology
The evidence investigator™ utilizes the basic principles of immunology; supporting competitive, sandwich and antibody capture immunoassay formats. The competitive assay utilizes an enzyme labeled analyte for signal production whereas the sandwich assay utilizes an enzyme labeled antibody. The chemiluminescence signals are simultaneously measured for the full array of tests on each chip.
ARRAYS:
Cardiac array
Cardiac biomarkers are enzymes, proteins and hormones that are associated with heart function, damage or failure. Some of the tests are specific for the heart while others are also elevated with skeletal muscle damage. Cardiac biomarkers are used for diagnostic and prognostic purposes and are frequently ordered by doctors when someone comes into A&E complaining of symptoms, such as chest pain, pressure, nausea, and shortness of breath.
The evidence investigator is a compact bench-top Biochip Array Technology analyser for the simultaneous analysis of a panel of tests in a single sample. The Clinical standards for research page gives an overview of Biochip Array Technology.
The cardiac array of tests are presented on a single biochip. All six tests are performed simultaneously using just one assay diluent, one panel-specific conjugate solution and one signal reagent.
Cardiac array test menu
Troponin I
Myglobin
CK-MB
Carbonic Anhydrase III (CA III)
Glycogen Phosphorylase BB (GPBB)
Fatty Acid Binding Protein (FABP)
The cardiac biochip measures 6 cardiac biomarkers from one patient sample revealing a great deal more information than a single test, this is the power of biochip array technology.
Cytokines & growth factors array
Cytokines and growth factors are proteins secreted primarily by immune system cells such as leucocytes. They are a means of intercellular communication with both immune and non-immune system cells. Upon binding to a cell membrane receptor, cytokines initiate a signal transduction cascade in their target cell. Cytokines form a complex web of interactions since:
· Different cytokines can have similar effects.
· Cells interact with a variety of cytokines.
· Cytokines may affect the activity and expression of other cytokines.
Cytokines and growth factors array test menu
Interleukin-1 alpha (IL-1a) 
Interleukin-1 beta (IL-1b)
Interleukin-2 (IL-2)
Interleukin-4 (IL-4)
Interleukin-6 (IL-6)
Interleukin-8 (IL-8)
Interleukin-10 (IL-10)
Interleukin-12 (IL-12) - in development
Vascular Endothelial Growth Factor (VEGF)
Tumour Necrosis Factor-alpha (TNF-a)
Interferon-gamma (IFN-g)
Epidermal Growth Factor (EGF)
Monocyte Chemotactic Protein-1 (MCP-1)
Adhesion molecules array
The adhesion molecules array of tests are presented on a single biochip. All five tests are performed simultaneously using just one assay diluent, one panel-specific conjugate solution and one signal reagent. The following adhesion molecule markers are measured on one biochip:
ICAM-I
VCAM-I
E - selectin
P - selectin
L - selectin
Drugs of abuse array I
Amphetamine
Methamphetamine
Cocaine
Barbiturates
Cannabinoids
Opiates
Methadone
Benzodiazepines
Lorazepam
Phencyclidine
Creatinine
Free thyroid array
Thyroid stimulating hormone (TSH)
Free tri-iodothyronine (FT3)
Free thyroxine (FT4
Total thyroid array
Thyroid stimulating hormone (TSH)
Total tri-iodothyronine (TT3)
Total thyroxine (TT4)
Fertility array
Follicle stimulating hormone (FSH)
Prolactin (PRL)
Lutenising Hormone (LH)
Estradiol*
Progesterone
Testosterone
Tumor monitoring array
Carcinoembryonic antigen (CEA)
a- Fetoprotein (AFP)
Human chorionic gonadotrophin (hCG)
Gastrointestinal tumour antigen (CA 19-9)
Ovarian Tumour antigen (CA 125)
Breast cancer antigen (CA 15-3)
Tumor PSA array
Total prostate specific antigen (tPSA)
Free prostate specific antigen (fPSA)
Carcinoembryonic antigen (CEA)
Cardiac array
Troponin I
Myoglobin
CK-MB
Carbonic Anhydrase III (CA III)
Glycogen Phosphorylase BB (GPBB)
Fatty Acid Binding Protein (FABP)
) 
Carbonic Anhydrase
CUSTOM BIOCHIPS
Produced on demand - Inquire***
Multi-analyte quality controls
Drugs of Abuse
Cardiac
Cytokine
Immunoassay
Customised quality controls
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